We support researchers throughout Wales and beyond with genome editing and transgenic technologies.
Transgenics is a powerful biomedical tool for modeling genetic disease, understanding pathophysiology and assessing new treatments for significant diseases such as cancer, dementia and many others. Wales Gene Park supports the development of genome editing and transgenic technologies and the production and use of the resulting pre-clinical models of rare and common diseases.
Bridget Allen, Genome Editing Research Manager, has many years of experience in the production of transgenic founders and chimeras with excellent success rates for IVF, cryopreservation and re-derivation, and more recent experience with CRISPR genome editing technologies. We can provide consultations and support for researchers throughout Wales in these techniques.
- Developing CRISPR genome editing technology to produce novel genetically modified (GM) models
- ES cell derivation
- Consultation provision for researchers requiring support in ES cell and genome editing techniques
- Continued use of exiting transgenic models for research into disease mechanisms and pre-clinical trials
Examples of work undertaken
- Prof. Ros John (BIOSI)
Developing a preclinical fetal programming model combining fetal growth restriction and aberrant behaviour.
- Prof. Trevor Dale (BIOSI)
Axin1 mutation drives hepatocellular carcinoma while reducing mutant b-catenin reverses intestinal hyperplasia.
Our microinjection rig is a combination of Nikon microscopes and Leica micro-manipulators giving clear images and fluid motion for precise micromanipulation.
The Genome Editing Facility is located within the Cardiff School of Biosciences.
For enquiries, please contact the Facility Manager at AllenBR@cardiff.ac.uk