Late onset familial alzheimer's disease

late onset familial alzheimers disease/ Alzheimer disease type 2

Posted 1 year ago by Wales Gene Park

Dementia is one of the major health issues facing medicine today, with an increasing number of patients due to a steadily ageing population. Much of what we know about the molecular basis of the various forms of dementia is due to studying rare inherited forms, caused by abnormalities (mutations) in the genes coding for several proteins, including the amyloid precursor protein, Presenilin 1 and 2, progranulin and tau. A major research issue when studying these disorders has been the lack of a valid cell model faithfully replicating the human disease. Recent advances in stem cell technology provide a method with which to develop novel, patientderived cell models for neuronal dysfunction in the dementias. We can take skin biopsies (fibroblasts) from patients who carry dementiacausing mutations and use a combination of factors to cause them to become stem cells. These induced pluripotent stem cells (iPS cells) can then be differentiated into...

 Late onset familial alzheimer's disease


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