Rare Non-specific

Posted 1 year ago by Wales Gene Park

Challenge: A Phase III Study Of The Impact Of A Physical Activity Program On Disease-Free Survival In Patients With High Risk Stage II Or Stage III Colon Cancer: A Randomised Controlled Trial CHALLENGE aims to determine whether a supervised physical activity (PA) programme in patients with high risk Stage II or Stage III colon cancer will improve 3- year disease-free survival (DFS) in comparison to standard care. The impact on patient-reported outcome measures (PROMS) and quality of life will also be assessed. There is compelling observational data that PA is associated with colon cancer incidence, recurrence, survival, and quality of life. The trial arms are: Intervention: A 36 month structured physical activity programme comprising supervised physical activity sessions and behaviour support sessions and provision of general health education materials (on diet and exercise). Standard Care: Provision of general health education materials on diet and exercise only.

 Rare Non-specific /  Velindre Cancer Centre

Posted 1 year ago by Wales Gene Park

National Study of Colorectal Cancer Genetics There are several different factors that can increase risk of developing bowel (colorectal) cancer. One is an inherited faulty gene (genetic mutation). An inherited genetic mutation may mean that several people in the same family develop bowel cancer. This is called a strong family history’. Inherited conditions such as familial adenomatous polyposis (FAP) or hereditary non-polyposis colorectal cancer (HNPCC) also increase risk. The increase in risk will depend on which gene is damaged, or even on which part of the gene is damaged. Some genetic mutations are ‘high penetrance’ and increase risk a lot. Others are ‘low penetrance’ and don’t increase risk very much. The aim of this study is to find out more about high penetrance genes, and how much they increase risk. And to look for new low penetrance genes.

 Rare Non-specific /  Wales Wide

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