A Prospective, Multicentre European Registry for Newly Diagnosed Patients With Myelodysplastic Syndromes (EUMDS)

 Chronic Myelomonocytic Leukemia (CMML) / Posted 4 days ago

Brief Summary

To collect and describe demographics, disease-management, and treatment outcomes of Myelodysplastic Syndromes (MDS) patients who are newly diagnosed and classified according to the World Health Organization (WHO) criteria.

To perform observational studies concerning relevant scientific research questions in MDS using clinical data and biological samples, and to present relevant research outcomes in the fields of diagnosis and prognostication, health related quality of life issues, health economics, and risk stratification for newly developed classes of drugs.

To disseminate results of the studies to all stakeholders involved.

Methodology

Data on patients with MDS will be collected prospectively at diagnosis and at 6-months intervals after diagnosis. The data will be gathered by seventeen (or more) countries that are represented within the LeukemiaNet MDS Working Party and will be combined in one central European Database. Data analyses will be conducted by the Data Management Centre at the University of York in various sub studies, at specific time points as decided or requested by the steering committee, but at least once a year included in the European Registry and at the end of the follow-up period.

Number of Patients & Centres Over 149 hematology centres in eighteen (or more) different countries (Austria, Croatia, Czech Republic, Denmark, France, Germany, Greece, Israel, Italy, The Netherlands, Romania, Spain, Sweden, Switzerland and United Kingdom) will participate as referral centres in this Registry. The recruitment target is a minimum of 3000 cases lower-risk MDS and 1000 higher-risk cases.

Population:

The study population will consist of newly diagnosed patients with all subtypes of MDS classified according to the WHO criteria, including therapy-related MDS and MDS-F, AML with 20-<30 percent marrow blasts (former RAEB-t), and CMML and other forms of mixed MDS/MPD.

Study Duration:

The enrolment time is scheduled to continue until at least December 2022 but extension of the recruitment period is possible. Patients will be followed until withdrawal (for any reason) or termination of the EUMDS Registry.

  • Inclusion Criteria :
    • Ages Eligible for Study: 18 Years and older (Adult, Older Adult)
    • Sexes Eligible for Study: All
    • Accepts Healthy Volunteers: No
    • Sampling Method: Probability Sample
    • Patients must meet all of the following criteria:
    • Age at least 18 years
    • Newly diagnosed patient (within 100 days from the date of the diagnostic bone marrow (BM) aspirate)
    • MDS classified according to current WHO criteria
    • All sub groups of MDS
    • Therapy-related MDS
    • MDS with Fibrosis (MDS-F)
    • AML with 20- 30 percent marrow blasts (former RAEB-t)
    • CMML and other forms of mixed MDS/MPD
    • IPSS and IPSS-R Risk group classification (mandatory)
    • Able and willing to provide the written informed consent
  • Exclusion Criteria :
    • Patient unwilling or unable to give consent
    • AML with ≥30 percent marrow blasts according to WHO
    • Patients with inv(16), t(5;17) and t(8;21) are considered AML and therefore not eligible
    • Patients with higher risk MDS progressed from a previously diagnosed lower risk MDS that was not registered within 100 days after first diagnosis of (lower risk) MDS
  • Study start date : April 2008
  • Study end date : June 30, 2023
  • Wales-Based Study Contact : Please speak to your clinicain
  • Principal Investigator : David Bowen, PhD (Leeds General Infirmary)
Contact details

Leeds General Infirmary Dept of HematologyLeeds,England,LS1 3EX  Show Phone Number corine.vanmarrewijk@radboudumc.nl www.leedsth.nhs.uk

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