A study to find out more about the causes of some types of lymphoma and chronic leukaemia

 Classic hairy cell leukemia / Posted 4 years ago

Conditions where lymphocytes have become cancerous are called lymphoproliferative disorders and include

  • Chronic lymphocytic leukaemia (CLL)
  • Mantle cell lymphoma
  • Follicular lymphoma
  • Hairy cell leukaemia
  • Splenic lymphoma with villous lymphocytes

Doctors want to find out more about these cancerous cells. In this study you will give samples of blood and any extra bone marrow or tissue you may have removed during routine procedures. You will also give a sample of spit (saliva). Researchers will look at both abnormal and normal cells in these samples. They will look for genes, including a particular gene called the ‘immunoglobulin gene’ that help the cancer cell to survive. And, for other gene and chromosome changes that may in future help them predict the outcome of these diseases.
The aim of this study is to understand more about how changes to certain genes, proteins and sugars could affect how these diseases develop. This may help develop new treatments for these conditions in future.
You will not have any direct benefit from taking part in this study, and it is unlikely to change your treatment plan in any way. But the results of the study will be used to help people with cancer in the future.

  • Inclusion Criteria : You can enter this study if you have any of the following cancers: Chronic lymphocytic leukaemia (CLL), Mantle cell lymphoma, Follicular lymphoma, Hairy cell leukaemia, Splenic lymphoma with villous lymphocytes (SLVL),
  • Study start date : 01/08/2002
  • Study end date : 31/12/2023
  • Wales-Based Study Contact : please speak to your clinician
  • Principal Investigator : Dr N K Potter

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