A trial looking at personalised therapy for people with cancer of unknown primary

 Rare Cancers (non-specific) / Posted 1 year ago

Researchers are looking at new ways to treat cancer. An area that they are looking at is personalised therapy.

Cancer cells have changes in their genes (DNA) that make them different from normal cells. These changes mean that they behave differently. It can also make one person’s cancer different to another’s.

A technique called genomic profiling can scan the genes of the cancer and identify those changes. Doctors hope they can match a treatment to your individual cancer.

The main aim of this trial is to find out whether personalised therapy is better than chemotherapy for people with CUP.

  • Inclusion Criteria :
    • have cancer that has spread to other parts of the body and doctors don’t know where the cancer started (cancer of unknown primary)
    • can’t have surgery or radiotherapy to cure your cancer have at least 1 area of cancer that can be seen and measured on a scan
    • are willing to have a sample of tissue taken (biopsy) if there isn’t a suitable sample taken in the past 3 months
    • are willing to have a blood test to look at your genes (genomic profile)
    • can have treatment with a platinum chemotherapy such as cisplatin or carboplatin
    • have satisfactory blood tests results
    • are well enough to carry out your normal activities, apart from heavy physical work (performance status of 0 or 1)
    • are willing to use reliable contraception during treatment and for up to 2 years afterwards if there is any possibility that you or your partner could become pregnant
    • are at least 18 years old
  • Exclusion Criteria :
    • have CUP that started in certain cells such as squamous cells (your doctor can tell you more about this) have cancer spread in the brain, spinal cord or the membranes that surround the brain (carcinomatous meningitis)
    • have had treatment for CUP, unless it was surgery or radiotherapy
    • have had another cancer in the last 5 years apart from carcinoma in situ of the cervix, non melanoma skin cancer or stage 1 womb cancer
    • have high levels of calcium (hypercalcaemia) that is causing symptoms
    • have liver problems such as hepatitis or cirrhosis
    • have heart problems such as angina that isn’t controlled, an irregular heart beat (arrhythmia) or you
    • have had a heart attack in the last 3 months
    • have had a major surgery in the last month, unless it was an operation to diagnose your cancer
    • have had an organ transplant or stem cell transplant from a donor
    • have had an investigational treatment in the past month
    • have HIV
    • have hepatitis B or hepatitis C
    • have active tuberculosis (TB)
    • drink an amount of alcohol that is a concern for your doctor
    • have any other medical condition that the trial team think could affect you taking part
    • are sensitive to any of the drugs used in this trial are pregnant or breastfeeding
  • Study start date : 11/07/2018
  • Study end date : 30/11/2020
  • Wales-Based Study Contact : please speak to your clinician
  • Principal Investigator : Dr Kai Keen Shiu

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