Small cell lung cancer / Posted 2 years ago
CHEMORES: A study to understand more about why chemotherapy to treat lung cancer can stop working
This study will look for changes in blood and tissue samples before and after treatment for lung cancer, to try to find out how cancer cells stop themselves being harmed by treatment.
Doctors may use surgery, radiotherapy, chemotherapy or another type of drug that targets lung cancer to treat this disease. Your treatment will depend on your type and stage of lung cancer. If you have non small cell lung cancer, you may have a combination of these. If you have small cell lung cancer, you would usually have chemotherapy.
We know from research that cancer cells can become ‘resistant’ to treatment. In lung cancer for example, cancer cells can sometimes reduce the concentration of the drug inside them, and repair DNA damage. And, develop changes in the genes in cancer cells that prevent the treatment from working.
Understanding why resistance happens will help develop improved treatment for lung cancer. This study is looking at genes and proteins in cancer cells in the blood and cancer tissue of people having lung cancer treatment such as chemotherapy containing platinum drugs . The main aim of this study is to find out why lung cancer often becomes resistant to treatment.