Small cell lung cancer / Posted 3 years ago

CHEMORES: A study to understand more about why chemotherapy to treat lung cancer can stop working

This study will look for changes in blood and tissue samples before and after treatment for lung cancer, to try to find out how cancer cells stop themselves being harmed by treatment.

Doctors may use surgeryradiotherapychemotherapy or another type of drug that targets lung cancer to treat this disease. Your treatment will depend on your type and stage of lung cancer. If you have non small cell lung cancer, you may have a combination of these. If you have small cell lung cancer, you would usually have chemotherapy.

We know from research that cancer cells can become ‘resistant’ to treatment. In lung cancer for example, cancer cells can sometimes reduce the concentration of the drug inside them, and repair DNA damage. And, develop changes in the genes in cancer cells that prevent the treatment from working.

Understanding why resistance happens will help develop improved treatment for lung cancer. This study is looking at genes and proteins in cancer cells in the blood and cancer tissue of people having lung cancer treatment such as chemotherapy containing platinum drugs Open a glossary item. The main aim of this study is to find out why lung cancer often becomes resistant to treatment.

  • Inclusion Criteria : Have small cell lung cancer, or non small cell lung cancer that is stage 3 or 4 Are due to have chemotherapy containing a platinum drug , or another type of drug that targets lung cancer such as erlotinib, gefitinib or crizotinib Have had a small sample of cancer tissue (a biopsy) removed from your lung, or you would be willing to have some tissue removed if appropriate Are well enough to take part
  • Exclusion Criteria : Are having treatment as part of a clinical trial (if your trial team are happy for you to also take part in this study, you can still take part) Are due to start a course of combined chemotherapy and radiotherapy (chemoradiation )
  • Study start date : 01/09/2007
  • Study end date : 30/03/2024
  • Wales-Based Study Contact : please speak to your clinician
  • Principal Investigator : Dr Fiona Blackhall

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