Investigation of clinical, serological and genetic factors in the development of arthritis and rheumatic diseases
Juvenile Idiopathic Arthritis / Posted 1 year ago
Arthritic and rheumatic diseases are chronic diseases caused by inflammation in joints, which can lead to permanent joint damage and disability. It is known that genetic factors, such as a change in DNA sequence, play a role in determining who will develop the disease. Some of these genetic sequence changes have already been identified, but there remain more to be discovered. Once a genetic change has been shown to be important in disease, it is necessary to find out how that sequence change contributes to the illness. Certain DNA changes, for example, may alter the amount (expression) of a protein produced. Protein expression can be measured from blood samples and compared to see if the genetic sequence change predicts the level of protein expression. Other genetic changes have no effect on protein expression, but may act inside individual cells to trigger inflammation. Often, in order to understand how a genetic change may predispose to disease, it is necessary to study what the sequence change does in people without the disease. For this reason, it is sometimes necessary to collect samples from healthy subjects. The aim of this study is to collect clinical information and blood samples from people with arthritic and rheumatic diseases and also from unaffected people. Genetic and protein expression data can be obtained from the blood samples.