Investigation of clinical, serological and genetic factors in the development of arthritis and rheumatic diseases

 Juvenile Idiopathic Arthritis / Posted 1 year ago

Arthritic and rheumatic diseases are chronic diseases caused by inflammation in joints, which can lead to permanent joint damage and disability. It is known that genetic factors, such as a change in DNA sequence, play a role in determining who will develop the disease. Some of these genetic sequence changes have already been identified, but there remain more to be discovered.   Once a genetic change has been shown to be important in disease, it is necessary to find out how that sequence change contributes to the illness. Certain DNA changes, for example, may alter the amount (expression) of a protein produced. Protein expression can be measured from blood samples and compared to see if the genetic sequence change predicts the level of protein expression.   Other genetic changes have no effect on protein expression, but may act inside individual cells to trigger inflammation. Often, in order to understand how a genetic change may predispose to disease, it is necessary to study what the sequence change does in people without the disease. For this reason, it is sometimes necessary to collect samples from healthy subjects.   The aim of this study is to collect clinical information and blood samples from people with arthritic and rheumatic diseases and also from unaffected people. Genetic and protein expression data can be obtained from the blood samples.

  • Inclusion Criteria :
    • Willing and able to sign consent.
    • Must have rheumatoid arthritis according to the American College of Rheumatology (ACR) 1987 criteria, psoriatic arthritis, Jeuvenile Idiopathic Arthritis, scleroderma, raynaud's disease or early inflammatory arthritis.
    • Must be of European Caucasian descent. It is necessary to restrict recruitment to those of European descent in order to reduce heterogeneity in the patient group for genetic studies. Frequencies of gene variants at different genetic markers differ between individuals from different ethnic groups and may introduce bias into any analysis.
  • Exclusion Criteria :
    • Either the individual, their general practitioner or consultant feels it is inappropriate for any reason for the patient to be enrolled.
    • Patients are unable or unwilling to provide informed consent or a blood sample.
    • Participation in a clinical trial that is testing a new drug treatment as these clinical trials usually insist that no other trial is undertaken during their trial.
  • Study start date : 01/01/2005
  • Study end date : 01/12/2020
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