Investigation of the Genetic and Molecular Pathogenesis of Primary Biliary Cirrhosis

 Primary Biliary Cirrhosis / Posted 1 year ago

The PBC Genetics Study is a national effort to establish a PBC DNA collection consisting of DNA samples from approximately 5000 patients with PBC. The DNA collection has already been used for a genome-wide association study (GWAS) of PBC.  The next major analysis will be a genome wide association study of response to Ursodeoxycholic acid (UDCA).

  • Inclusion Criteria : Adult, able to provide informed consent, satisfies case definition of PBC.
  • Exclusion Criteria : Child or unable to provide informed consent.
  • Study start date : 06/12/2007
  • Study end date : 28/03/2021
  • Wales-Based Study Contact :
    • Andrew Yeoman (Nevill Hall Hospital, Royal Gwent Hospital & Ysbyty Ystrad Fawr)
    • Caroline Morris (Glan Clwyd Hospital, Llandudno General Hospital, Wrexham Maelor Hospital, Ysbyty Gwynedd)
    • Caradog Thomas (Glangwili General Hospital, Prince Philip Hospital, Morriston Hospital, Neath Port Talbot Hospital, Singleton Hospital)
    • Rachel Hughes (Withybush General Hospital)
    • Tom Yapp (Princess of Wales Hospital)
    • Sarah Jones (Bronglais Hospital)
    • Meryl Rees (Royal Glamorgan Hospital, Ysbyty Cwm Cynon)
    • Caroline Hamilton (Prince Charles Hospital)
  • Principal Investigator :
    • Andrew Yeoman (Nevill Hall Hospital, Royal Gwent Hospital, Ysbyty Ystrad Fawr)
    • David Ramanaden (Glan Clwyd Hospital)
    • Richard Evans (Llandudno General Hospital)
    • Thiriloganathan Mathialahan (Wrexham Maelor Hospital)
    • Jaber Gasem (Ysbyty Gwynedd)
    • Tom Yapp (Princess of Wales Hospital)
    • Minesh Patel (Prince Charles Hospital, Royal Glamorgan Hospital, Ysbyty Cwm Cynon)
    • Mark Narain (Bronglais Hospital)
    • Imroz Salam (Glangwili General Hospital)
    • Ian Rees (Prince Philip Hospital)
    • Chin Lye Chng (Morriston Hospital, Singleton Hospital)
    • Mesbah Rahman (Neath Port Talbot Hospital)
Contact details

Wales Wide add-tr.ukpbc@nhs.net

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