Investigation of the Genetic and Molecular Pathogenesis of Primary Biliary Cirrhosis
Primary Biliary Cirrhosis / Posted 2 years ago
The PBC Genetics Study is a national effort to establish a PBC DNA collection consisting of DNA samples from approximately 5000 patients with PBC. The DNA collection has already been used for a genome-wide association study (GWAS) of PBC. The next major analysis will be a genome wide association study of response to Ursodeoxycholic acid (UDCA).
- Inclusion Criteria : Adult, able to provide informed consent, satisfies case definition of PBC.
- Exclusion Criteria : Child or unable to provide informed consent.
- Study start date : 06/12/2007
- Study end date : 28/03/2021
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Wales-Based Study Contact :
- Andrew Yeoman (Nevill Hall Hospital, Royal Gwent Hospital & Ysbyty Ystrad Fawr)
- Caroline Morris (Glan Clwyd Hospital, Llandudno General Hospital, Wrexham Maelor Hospital, Ysbyty Gwynedd)
- Caradog Thomas (Glangwili General Hospital, Prince Philip Hospital, Morriston Hospital, Neath Port Talbot Hospital, Singleton Hospital)
- Rachel Hughes (Withybush General Hospital)
- Tom Yapp (Princess of Wales Hospital)
- Sarah Jones (Bronglais Hospital)
- Meryl Rees (Royal Glamorgan Hospital, Ysbyty Cwm Cynon)
- Caroline Hamilton (Prince Charles Hospital)
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Principal Investigator :
- Andrew Yeoman (Nevill Hall Hospital, Royal Gwent Hospital, Ysbyty Ystrad Fawr)
- David Ramanaden (Glan Clwyd Hospital)
- Richard Evans (Llandudno General Hospital)
- Thiriloganathan Mathialahan (Wrexham Maelor Hospital)
- Jaber Gasem (Ysbyty Gwynedd)
- Tom Yapp (Princess of Wales Hospital)
- Minesh Patel (Prince Charles Hospital, Royal Glamorgan Hospital, Ysbyty Cwm Cynon)
- Mark Narain (Bronglais Hospital)
- Imroz Salam (Glangwili General Hospital)
- Ian Rees (Prince Philip Hospital)
- Chin Lye Chng (Morriston Hospital, Singleton Hospital)
- Mesbah Rahman (Neath Port Talbot Hospital)