Small cell lung cancer / Posted 12 months ago

LUCID: A study looking at breath samples to find out if these can help to diagnose lung cancer

This study is for people who have been referred for tests because they might have lung cancer.

Researchers would like to develop a test to pick up lung cancer at an earlier stage. This way, more people could have a chance of successful treatment.

Research has shown that cells inside the body make substances that end up in the lungs. These substances are then breathed out. Researchers think that the substances may be different if a person has lung cancer.

This study will look at biomarkers in a person’s breath. Biomarkers are substances in the body that can be measured. Some biomarkers can help doctors to diagnose cancer, predict whether a treatment will work and show whether treatment is working.

The aims of this study are to

  • learn more about the different biomarkers in breath
  • find out if breath can be used to help detect lung cancer earlier
  • Inclusion Criteria :
    • Have certain symptoms or abnormal scan results that could be due to lung cancer and your doctor has referred you for tests
    • Are able to understand written and spoken English
    • Are at least 18 years old
  • Exclusion Criteria :
    • Have breathing problems (either very rapid or very slow breathing) or respiratory failure
    • Would not be able to manage wearing the facemask for example because you have claustrophobia
    • Are already taking part in another trial looking at a treatment
    • Have had a sample of lung tissue (lung biopsy) taken in the last 48 hours
    • Have had a certain type of lung function test using metacholine or beta-2-sympatico mimetic in the last 2 hours
    • Are already having treatment for lung cancer
  • Study start date : 01/02/2016
  • Study end date : 31/12/2020
  • Wales-Based Study Contact : please speak to your clinician
  • Principal Investigator : Dr Robert Rintoul

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