Rare Cancers (non-specific) / Posted 1 year ago

MICROBIOME- A study of MRx0518 before surgery for solid tumours
This study is looking at a new treatment called MRx0518 for solid tumours.

  • Inclusion Criteria : You may be able to join this study if you have 1 of the following types of cancer: Melanoma, Breast, Ovarian, Womb, Prostate, Bladder, Kidney, Lung, Head and neck, Cancer of the tube that carries urine from the kidney to outside the body (the urethra)
    • As well as the above, the following must also apply.
    • are due to have surgery to remove the cancer 2 to 4 weeks after treatment
    • can swallow and keep medication down
    • are willing to use reliable contraception for at least 28 days before starting treatment, during treatment and for 3 months after last dose for men and one complete menstrual cycle for women if there is any chance you or your partner could become pregnant
    • have satisfactory blood test results
    • are well enough to be up and about for at least half the day (performance status 0,1 or 2)
    • are at least 18 years old
  • Exclusion Criteria :
    • have had cancer treatment in the last 2 years
    • have cancer of the digestive system such as the stomach or bowel or if you might need to have part of your bowel removed
    • are having an experimental cancer treatment or any other treatment for cancer
    • have cancer that has grown into surrounding tissue and it isn’t possible to remove it with surgery
    • have heart problems such as a problem with the valves in the heart, congestive heart failure or any other serious heart problem
    • have a feeding tube into the stomach, an abnormal opening in the stomach (a fistula) or inflammatory bowel disease such as a condition called ulcerative colitis have a problem with your immune system or you are having medication to dampen down your immune system
    • have a problem with your digestive system that means you won’t be able to absorb the study medication
    • have an active infection
    • have an active hepatitis B or hepatitis C infection have HIV
    • have had antibiotics with 4 weeks of starting study treatment
    • have had flu, a fever, meningitis or an infection within 4 weeks of starting study treatment
    • have any other medical condition or mental health problem that the study team think would affect you taking part
    • drink a lot of alcohol (more than 14 units each week)
    • smoke or use nicotine, this includes e cigarettes
    • are allergic to MRx0518 or anything it contains
    • are allergic to amoxicillin (clavulanic acid), erythromycin and imipenem
    • are pregnant or breastfeeding
  • Study start date : 10/04/2019
  • Study end date : 30/04/2021
  • Wales-Based Study Contact : Not recruiting in Wales
  • Principal Investigator : Dr Jonathan Krell

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