REGAIN- Rolandic Epilepsy Genome Wide Association International Study

 Rolandic epilepsy / Posted 3 years ago

Approximately 25% of children with epilepsy have “Rolandic Epilepsy” or RE, also known as Benign Epilepsy with Centrotemporal Spikes (BECTS). RE is diagnosed with the help of an electroencephalograph (EEG) or brainwave test. Children with RE quite often have other symptoms that affect their speech, attention, reading ability or coordination.

We know that RE has a genetic basis and we recently discovered the genetic cause of the EEG pattern seen in RE. The goal of REGAIN is to now find the genetic basis for susceptibility to seizures and the associated symptoms above. Our hope is to be able to improve diagnosis and understand why each child with RE is different, and perhaps point us towards new treatments that are more effective and have fewer side effects.

We will compare the genetic code of 3,000 children with RE against a similar number of people not affected by epilepsy. With the proposed large sample of participants, we will be able to pinpoint the exact changes that might lead to seizures or attention problems for example.

  • Inclusion Criteria : Anyone aged from 6-25 years who has been diagnosed currently or in the past with Rolandic Epilepsy and has had an EEG that supports this diagnosis.
  • Wales-Based Study Contact : Not recruiting in Wales
  • Principal Investigator : Professor Deb Pal

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