Rare Non-specific / Posted 2 years ago

National Study of Colorectal Cancer Genetics

There are several different factors that can increase risk of developing bowel (colorectal) cancer. One is an inherited faulty gene (genetic mutation).
An inherited genetic mutation may mean that several people in the same family develop bowel cancer. This is called a strong family history’. Inherited conditions such as familial adenomatous polyposis (FAP) or hereditary non-polyposis colorectal cancer (HNPCC) also increase risk.
The increase in risk will depend on which gene is damaged, or even on which part of the gene is damaged. Some genetic mutations are ‘high penetrance’ and increase risk a lot. Others are ‘low penetrance’ and don’t increase risk very much.
The aim of this study is to find out more about high penetrance genes, and how much they increase risk. And to look for new low penetrance genes.

  • Inclusion Criteria : Patients aged 18-59 at date of diagnosis, who have had a diagnosis of adenocarcinoma of the colon or rectum within the last five years. Patient must have a family history of bowel cancer (parent/sibling/child also diagnosed).
  • Exclusion Criteria : Patients will be excluded if they do not meet the inclusion criteria.
  • Study start date : 02/06/2003
  • Study end date : 30/09/2021
  • Wales-Based Study Contact : please speak to your clinician
  • Principal Investigator : Prof Richard Gray
Contact details

Bronglais General Hospital, Withybush General Hospital, Glangwili General Hospital, Wrexham Maelor, Glan Clwyd Hospital, Ysbyty Gwynedd, Nevill Hall, University Hospital of Wales, Velindre Cancer Centre. Wales Wide nsccg.study@icr.ac.uk www.cancerresearchuk.org

No post found