Parkinson's Families Project (PFP)

 Autosomal Recessive Juvenile Parkinson Disease / Posted 2 years ago

One person in every 500 has Parkinson’s and around 127,000 people are living with the condition in the UK. The aim of the study is to identify new genes that predispose or cause Parkinson’s Disease or Parkinsonism. There is a pressing need to study the genetic makeup of family members both with and without Parkinson’s. As families share a common genetic background, it is easier to find new Parkinson’s genes by studying the genetic makeup of people with Parkinson’s alongside other members of their families. We are particularly interested in studying the genetic makeup of two groups of people:

  1. those who developed Parkinson’s before the age of 45; and
  2. those who have a family history of other relatives affected by Parkinson’s.

By identifying genetic factors that cause Parkinson’s, we hope to understand more about the condition. Doing so will lead to the development of better diagnosis, improved disease models, and we hope in time, to the development of better treatment.

  • Inclusion Criteria : Ages Eligible for Study: 16 Years and older (Child, Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: Yes Clinical diagnosis of Parkinson's disease or parkinsonism, and either family history of Parkinson's/parkinsonism (first or second degree family member affected by Parkinson's or parkinsonism) AND/OR Early onset Parkinson's/parkinsonism (symptom onset before the age of 45 years) First or second degree family member of an Index Case, affected or unaffected by Parkinson's/parkinsonism. Aged over 16 years
  • Exclusion Criteria : Lack of capacity to consent to participate in the project.
  • Study end date : 31/01/2027
  • Wales-Based Study Contact : Please speak to your clinician
  • Principal Investigator : Huw Morris, PhD, FRCP University College, London

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