(Pathway 1) SIOP Ependymoma Program II

 Ependymoma (on the brain) / Posted 1 year ago

This trial is looking at treating ependymoma with chemotherapy after surgery and radiotherapy. It is open to children and young adults whose ependymoma has been completely removed by surgery. Cancer Research UK supports this trial.
There are 2 parts to this trial. In the 1st part the trial committee looks at the results of your tests and scans. The 2nd part is looking at treatment pathways.
There are 3 treatment pathways in this trial. This information is about pathway 1. We also have information on pathway 2 and pathway 3.

The aims of this trial are to find out
how well chemotherapy after surgery and radiotherapy works to stop ependymoma coming back
about the side effects of having chemotherapy after surgery and radiotherapy
how safe it is to give chemotherapy after surgery and radiotherapy

  • Inclusion Criteria :
    • Have been newly diagnosed with an ependymoma in the brain that is grade 2 or grade 3
    • Have had surgery to remove your tumour
    • Have had an MRI scan after surgery and if there is any tumour left it measures less than 5mm
    • Have had an MRI scan and a lumbar puncture that shows your tumour has not spread to the spine
    • Are able to have radiotherapy and chemotherapy
    • Have satisfactory blood test results
    • Are willing to use reliable contraception during treatment and for 6 months afterwards if you are sexually active and you or your partner could become pregnant
    • Are between 1 year and 22 years old
  • Exclusion Criteria :
    • You have been diagnosed with an ependymoma called a subependymoma, ependymomablastoma or myoxopapillary ependymoma
    • You have already had radiotherapy
    • You have already had chemotherapy apart from steroids
    • Your ependymoma started in the spine
    • You are already having treatment with another anti tumour drug
    • You are already taking part in another clinical trial looking at treatment for ependymoma
    • You are unable to have any of the drugs used in the trial for any reason
    • You have an infection
    • There is a medical or another reason why you can’t have the amounts of fluids you need as part of the treatment in this trial
    • You have any other medical condition or mental health problem that the trial team think could affect you taking part
    • You are pregnant or breastfeeding
  • Study start date : 12/02/2016
  • Study end date : 11/02/2021
  • Wales-Based Study Contact : please speak to your clinician
  • Principal Investigator : Professor R Grundy

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