(Pathway 3) SIOP Ependymoma Program II
Ependymoma (on the brain) / Posted 1 year ago
Ependymoma is a type of brain tumour that mostly affects children and young people. We use the term ‘you’ in this summary, but if you are a parent, we are referring to your child.
Doctors usually treat ependymoma by removing it with surgery. After surgery if you can’t have radiotherapy you have chemotherapy instead.
In this pathway researchers want to find out if adding a drug called valproic acid to chemotherapy improves treatment.
Valproic acid is a drug that blocks substances (enzymes ) in the body called histone deacetylases (pronounced dee-as-et-isle-azes). Cells need these to grow and divide. Blocking them may stop cancer growing. Drugs that block these enzymes are called histone deacetylase inhibitors or HDAC inhibitors.
We know from research that valproic acid can help people with other types of brain tumours.
The aims of this pathway are to find how well chemotherapy with valproic acid works for young children and those who can’t have radiotherapy to treat ependymoma what the side effects of valproic acid and chemotherapy are how safe it is to give valproic acid with chemotherapy