(Pathway 3) SIOP Ependymoma Program II

 Ependymoma (on the brain) / Posted 1 year ago

Ependymoma is a type of brain tumour that mostly affects children and young people. We use the term ‘you’ in this summary, but if you are a parent, we are referring to your child.

Doctors usually treat ependymoma by removing it with surgery. After surgery if you can’t have radiotherapy you have chemotherapy instead.

In this pathway researchers want to find out if adding a drug called valproic acid to chemotherapy improves treatment.

Valproic acid is a drug that blocks substances (enzymes ) in the body called histone deacetylases (pronounced dee-as-et-isle-azes). Cells need these to grow and divide. Blocking them may stop cancer growing. Drugs that block these enzymes are called histone deacetylase inhibitors or HDAC inhibitors.
We know from research that valproic acid can help people with other types of brain tumours.

The aims of this pathway are to find how well chemotherapy with valproic acid works for young children and those who can’t have radiotherapy to treat ependymoma what the side effects of valproic acid and chemotherapy are how safe it is to give valproic acid with chemotherapy

  • Inclusion Criteria :
    • Have been diagnosed with an ependymoma in the brain that is grade 2 or 3
    • Have satisfactory blood test results
    • Are able to have chemotherapy
    • Are under 1 year old or you are older but not able to have radiotherapy
  • Exclusion Criteria :
    • You have been diagnosed with an ependymoma called a subependymoma, ependymomablastoma or myoxopapillary ependymoma
    • Your ependymoma started in the spine
    • You have already had chemotherapy
    • You have already had radiotherapy
    • You are already having treatment with another anti tumour drug
    • You are already taking part in another clinical trial looking at treatment for ependymoma
    • You have severe damage to your liver or kidneys
    • There is a family history of severe epilepsy
    • You are unable to have any of the drugs used in the trial for any reason
    • There is a medical or other reason why you can’t have the amounts of fluids you need as part of the treatment in this trial
    • You have another medical problem that the trial team think could affect you taking part
  • Study start date : 12/02/2016
  • Study end date : 11/02/2021
  • Wales-Based Study Contact : please speak to your clinician
  • Principal Investigator : Professor R Grundy

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