(Pathway 3) SIOP Ependymoma Program II

 Ependymoma (on the brain) / Posted 1 year ago

This trial is looking at adding valproic acid to chemotherapy after surgery to treat ependymoma. It is open to children younger than 1 year old and those with an ependymoma who can’t have radiotherapy after surgery to remove their tumour. Cancer Research UK supports this trial.
There are 2 parts to this trial. In the 1st part the trial committee looks at the results of your tests and scans. The 2nd part is looking at treatment pathways.
There are 3 treatment pathways in this trial. This information is about pathway 3. We have information on pathway 1 and pathway 2.

  • Inclusion Criteria :
    • Have been diagnosed with an ependymoma in the brain that is grade 2 or 3
    • Have satisfactory blood test results
    • Are able to have chemotherapy
    • Are under 1 year old or you are older but not able to have radiotherapy
  • Exclusion Criteria :
    • You have been diagnosed with an ependymoma called a subependymoma, ependymomablastoma or myoxopapillary ependymoma
    • Your ependymoma started in the spine
    • You have already had chemotherapy
    • You have already had radiotherapy
    • You are already having treatment with another anti tumour drug
    • You are already taking part in another clinical trial looking at treatment for ependymoma
    • You have severe damage to your liver or kidneys
    • There is a family history of severe epilepsy
    • You are unable to have any of the drugs used in the trial for any reason
    • There is a medical or other reason why you can’t have the amounts of fluids you need as part of the treatment in this trial
    • You have another medical problem that the trial team think could affect you taking part
  • Study start date : 12/02/2016
  • Study end date : 11/02/2021
  • Wales-Based Study Contact : please speak to your clinician
  • Principal Investigator : Professor R Grundy

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