Generalized pustular psoriasis / Posted 2 years ago

Pustular psoriasis: eLucidating Underlying Mechanisms

Pustular forms of psoriasis are characterised by painful, intensly inflamed, red skin studded with sterile pustules. The disease may be chronic and localised, typically to the hands and feet, or, more rarely, more generalised across the body and potentially life-threatening. Although pustular psoriasis accounts for less than 10% of psoriasis cases it consistently ranks highest among all variants in terms of symptoms and functional impairment. There is recent evidence, including work from our own group, to suggest that distinct underlying genetic and molecular pathways found in patients with pustular disease could be responsible for this particular disease presentation. The poor response to therapies used to great effect in other types of psoriasis may also be expla
In PLUM we aim to identify and understand the genes that may have an influence on the development of pustular psoriasis, related immune pathways and responses to treatment. We will recruit patients, disease controls, healthy volunteers and relations of patients and invite them to donate blood samples, and optional skin and hair pluck samples.

  • Inclusion Criteria : 1. Patients with pustular psoriasis (including generalised pustular psoriasis, acrodermatitis continua of Hallopeau and palmar plantar pustulosis) diagnosed by a trained dermatologist 2. Family members of patients with pustular psoriasis 3. Healthy volunteers who do not have a family history of plaque psoriasis or inflammatory skin disease 4. Patients affected by other autoinflammatory syndromes or neutrophilic dermatoses, diagnosed by a trained specialist (e.g. a nephrologist, rheumatologist or dermatologist)
  • Exclusion Criteria : 1. Individuals unable to give written informed consent 2. Individuals who have received a blood transfusion within 4 weeks 3. Individuals who are known to be infected with HIV, HBV or other blood-borne viruses
  • Study start date : 15/03/2017
  • Study end date : 31/12/2021
  • Wales-Based Study Contact : Bethan Morse
  • Principal Investigator : Prof Catherine Smith

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