Treatment of osteogenesis imperfecta with parathyroid hormone and zoledronic acid

 Osteogenesis imperfecta / Posted 11 months ago

Osteogenesis imperfect (OI) or brittle bone disease is an inherited condition in which the bones of the skeleton break (fracture) more easily than normal, often in response to a minor injury and sometimes for no reason at all. There is no cure for OI and no treatment has been convincingly shown to reduce the risk of breaking bones. Many doctors treat OI patients with drugs called bisphosphonates, such as zoledronic acid, which are also used in osteoporosis (gradual bone loss that leads to weakened bones), but it’s not clear if they are effective at preventing fractures in OI. Teriparatide (TPTD) is a form of parathyroid hormone, which works by activating bone building cells in the body. The aim of this study is to determine if it is possible to reduce the risk of fractures occurring in OI by using a combination of treatments which will strengthen the skeleton as compared with standard care.

  • Study start date : 01/02/2017
  • Study end date : 30/03/2023
  • Wales-Based Study Contact : please speak to your clinician
Contact details
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Northern General Hospital Sheffield S5 7AU Addenbrooke's Hospital Cambridge CB2 0QQ Leicester Royal Infirmary Leicester LE1 5WW Queen Elizabeth Hospital Birmingham B15 2TH Freeman Hospital Newcastle Upon Tyne NE7 7DN Ninewells Hospital Dundee DD1 9SY Royal Victoria Hospital Belfast BT12 6BA Queen Elizabeth University Hospital Glasgow G51 4TF Manchester Royal Infirmary Manchester M13 9WL Bristol Royal Infirmary Bristol BS2 8HW Nuffield Orthopaedic Centre Oxford OX3 7HE Royal National Orthopaedic Hospital Stanmore HA7 4LP Wishaw General Hospital Wishaw ML2 0DP NHS Lothian Western General Hospital Edinburgh EH4 2XU St Vincent's Hospital Dublin 4 Aberdeen Royal Infirmary Aberdeen AB25 2ZR Royal Liverpool Hospital Liverpool L7 8XP Llandough University Hospital Llandough CF64 2XX Guy's and St Thomas' Hospital London SE1 9RT James Cook University Hospital Middlesbrough PS4 3BW Norfolk and Norwich University Hospital Norwich NR4 7UQ Nottingham City Hospital Nottingham NG5 1PD Queen Alexandria Hospital Portsmouth P06 3LY University Hospital Southampton Southampton S016 6YD Haywood Community Hospital Stoke-on-Trent ST6 7AG
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 holly.ennis@ed.ac.uk bepartofresearch.nihr.ac.uk

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